Reawakening Apoptosis in Cancer Cells: The Advent of BH3-Mimetic Drugs

The uniquely fatal nature of cancer lies in unhindered proliferation, which bypasses the apoptotic machinery within the cells. Apoptosis refers to programmed cell death, a form of ‘cellular suicide’ that is regulated by altering the activity of specific proteins. Apoptosis is an orderly process that is initiated by the permeabilization of the cell’s plasma membrane, which leads to fragmentation of its DNA by activated caspase cascades and ultimately, cell death (Renehan et al., 2001)…